| Project leader |
Project title |
| Aguzzi |
Genetic isolation of key prion protein interactors by phenotype suppression screens in Drosophila |
|
Diagnostic, Prognostic, and Therapeutically Relevant Prion Co-Factors: An Approach Based on Functional Genomics |
|
C5 Function of the cellular prion protein PrPC, and of its homologue, Dpl |
|
Investigating the neuroimmunology of Alzheimer`s and prion diseases
in a humanized mouse model |
|
Functional genomics approach to identify general molecular pathogenetic mechanisms underlying neurodegenerative disorders |
|
An integrated immunological and cellular strategy for sensitive TSE diagnosis and strain discrimination |
|
Investigation of the role of the cysteine protease inhibitor Cystatin F in neurodegenerative diseases and assessment of its use as a predictive marker for patient screening in body fluids |
|
Understanding peripheral prion pathogenesis |
|
Characterization of prion strains present in Swiss Creutzfeldt-Jakob disease victims |
|
Application of the Transient Scrapie Cell Assay (TraSCA) for in vitro detection of ovine and bovine prions |
|
Germinal center B cells are dispensable in prion transport and neuroinvasion |
|
Prion strain discrimination using luminscent conjugated polymers |
|
Characterisation of the prion strains present in Swiss Creutzfeldt-Jakob Disease patients |
|
Assessment of candidate secreted surrogate biomarkers for early diagnosis of prion disease in farm animals |
|
Application of the transient Scrapie cell assay (TRASCA) for in vitro detection of ovine and bovine prions |
|
Strains, Species and Immunology in Prion Diseases |
|
Efficient prion transmission via the intranasal and aerosolic route |
|
Analysis of the physiological and pathological role of prion protein by proteomic approach in vivo |
| Arrighi |
Validation and characterization of novel interaction partners of PrPC and Doppel |
|
Immunotherapeutic strategies against prion diseases |
| Arrighi Zabel |
Role of complement in prion pathogenesis
|
| Baumann |
Correlation studies of the topology of PrP and brain damage |
| Baumann Pahnke |
Functional Analysis of PrP subdomains |
| Braun |
Elucidation of the physiological function of the prion protein |
| Bremer |
Physiological function of the prion protein in myelin maintenance |
| Brunner Braun |
Sensitive quantification of PrPSc using mass spectrometry |
| Brunner Seeger |
Discovery and quantification of TSE markers using mass spectrometry |
| Calella |
Analysis of the physiological and pathological role of prion protein by proteomic approach in vivo |
| Genoud |
Block of prion replication by a soluble dimeric form of PrP |
|
Generation and functional analysis of mice lacking Dpl and PrP/Dpl |
| Glatzel |
Role of the peripheral nervous system in prion neuroinvasion |
|
Human prion diseases in Switzerland: Investigation of clinical, genetic, histological and biochemical profiles |
| Heikenwälder |
Do chronic inflammations modulate prion pathogenesis? |
|
Cellular recognition of host and pathogenic DNA: investigating TLR signalling pathways and receptors |
|
Understanding human prions strains by humanizing the immune system of mice |
|
Dissection of mechanisms in the development of chronic hepatitis induced hepatocellular carcinoma |
|
Molecular dissection of hepatocellular carcinogenesis in mice with chronic hepatitis, a mouse model of hepatitis associated human hepatocellular carcinoma |
|
Molecular and cellular dissection of hepatocellular carcinogenesis in mice with chronic hepatitis |
| Heikenwaelder |
Ectopic generation of FDCs to elucidate the function of B-cells and FDCs in peripheral prion pathogenesis |
|
Does the relative distance between FDCs and hot spots of innervation determine neuroinvasion? |
|
The role of functional germinal center B-cells in prion pathogenesis |
| Heppner |
Analysis of a SOD-like activity of the cellular prion protein in vivo |
|
Induction of protective immune responses against prion diseases |
|
The contribution of microglia to scrapie pathogenesis |
| Huber |
Contribution of Follicular Dendritic Cells to peripheral Prion Accumulation |
|
Molecular Characterization of Follicular Dendritic Cells, a Key Player in Prion Pathogenesis |
| Maissen |
Rescue of Scrapie-infected Mouse Neuroblastoma (N2aSc) Cells |
| Miele |
Assessing the role of progenitor cells of the erythroid lineage in prion pathogenesis |
|
Identification of genes differentially expressed in lymphoid organs during the preclinical phase of prion pathogenesis |
| Miele Genoud |
Identification of genes differentially expressed in testes of Prion protein and Doppel double knockout mice |
| Neumann |
Functional consequences of mutations in the TARDBP gene associated with amyotrophic lateral sclerosis |
|
TDP-43 as disease protein in FTLD-U and ALS: Transgenic models for TDP-43 proteinopathies and physiologic function of TDP-43 in the brain. |
|
Large-scale RNAi screen to identify kinases modulating TDP-43 phosphorylation state |
| Nilsson |
Prion conformation probed by Conjugated Polyelectrolytes |
| Ott |
Engineering of dominant-negative mutant of prion protein for therapeutic and diagnostic applications |
| Pahnke |
Investigations of the involvment of CD8-lymphocytes in the propagation of cerebral prion replication |
| Polymenidou |
Development of a non-invasive blood-based prion diagnostic method: Investigation of PrPC and PrPSc plasma levels after peripheral administration of novel anti-PrP antibodies |
| Radovanovic |
Mutant PrPC and Prion Homologue Dpl Induced Neurodegeneration Mechanisms |
| Seeger Brunner |
Identification of Marker Proteins for Prion Disease in Urine |
| Seeger Maissen |
Identification of Interaction Partners of the Prion Protein Homologue Doppel |
| Sigurdson |
Investigations of Immunization Strategies against Chronic Wasting Disease in Deer and Elk |
|
Mechanism of prion infectivity generation by genetics |
|
Investigation of sheep scrapie transmission via milk from the inflamed mammary gland |
|
Does gastrointestinal microflora influence prion disease susceptibility or kinetics? |
|
Does the unique fixed loop in the elk prion protein alter TSE pathogenesis or susceptibility? |
| Sponarova |
Investigation of the role of innate and acquired immune mechanisms in generation or natural clearance of AA amyloid |
| Zabel |
Using cell contact-mediated ablation of microglia to decipher their role in prion pathogenesis |
| Zeller |
Are Langerhans cells implicated in transport of PrpSC from periphery to lymphoid organs? |
|
Ectopic Expression of Lymphotoxins in a non-lymphoid organ |
|
Investigation of the role of microglia in Prion disease by cell specific ablation of microglia in vivo |
