ZIHP Zürcher Zentrum für Integrative Humanphysiologie more information

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Current research projects

Project leader	Project title
Bloch	Sleep, breathing and psychomotor performance at altitude
Cannizzaro	Role of vasopressin on surfactant release and ventilation in the developing lung
Cohen	From fish to man: Relevance of glucocorticoids for renal development and epithelial cell function in health and disease
Devuyst	Role of the renal proximal tubule in metabolism: From physiology to rare diseases
French	Role of innate immunity and drug metabolism in severe cutaneous adverse drug reactions: from physiology to disease
Gassmann	Enhanced cognitive functioning and memory by hypoxia and erythropoietin?
Goede	N-methyl-D-aspartate receptors in red blood cells of mice and men: intracellular Ca2+ as a therapeutic target for the treatment of sickle cell disease
Grimm	Paraoxonase-1: A detoxifying enzyme linking pathophysiological mechanisms from heart to retina
Hagmann	Executive function in preterm born children: an integrative approach from genetics to brain function
Hornemann	The role of deoxy-sphingoid bases in diabetes mellitus and the diabetic sensory neuropathy
Landolt	Inhibiting COMT - neuroprotection and wake promotion?
Lutz	Immediate improvement of lipid metabolism, liver and endothelial function after Roux-en-Y gastric bypass (RYGB) surgery in obese humans and rodents
Matter	Sirtuins in the immune system: From physiology to auto-inflammatory and auto-immune diseases
O'Gorman	Linking the major system markers for typical and atypical brain development: a multimodal imaging and spectroscopy study
Rasmussen	Multimodal assessment of brain and muscle as biological basis to understand fatigue
Schaer	Hemoglobin associated pathology – mechanisms, biomarkers and novel therapeutic strategies
Scharl	The role for protein tyrosine phosphatase non-receptor type 2 (PTPN2) in inflammatory bowel disease, rheumatoid arthritis and colorectal carcinoma
Serra	The role and regulation of fibroblast growth hormone 23 (FGF23) in health and chronic kidney disease (CKD)
Straumann	Using zebrafish mutant belladonna and hypopigmented mice as disease models to study congenital nystagmus in human patients
von Eckardstein	Circulating microRNAs as mediators and biomarkers of the metabolic syndrome and its clinical complications

Completed research projects

Project leader	Project title
Bogdanova	Erythropoietin: protecting the heart from cold global ischemia-reperfusion injury
Brandeis	Thalamocortical interaction in brain state regulation during normal development and in epilepsy
de Quervain	The physiology of human emotional memory: An integrative project using human genetics and functional neuroimaging
Donath	Role of inflammatory mediators in metabolic stress: from physiology to pathology
Hennet	Protective action of maternal milk in gastrointestinal physiology
Huber Wolf	Synaptic homeostasis in normal and mentally retarded children and adolescents: from genes to behavior
Kullak-Ublick	Regulation and functional characterization of transporters for drugs and endogenous substances in the human intestine
Landolt Jenni	Sleep and cognition of children and adults in health and disease: a cooperative and integrative approach
Lutz	Disturbed eating at high altitude
Maggiorini	Mechanisms of dexamethasone and erythropoietin on ventilatory response, pulmonary artery pressure and pulmonary edema in high altitude
Matter	Vulnerable atherosclerotic plaques: Early detection, functional imaging, targeted treatment
Ogunshola	Cytoskeleton-mediated hypoxic signalling: Rho GTPases and degenerative disease
Rogler	Role of pH receptors for intestinal inflammation
Straumann	Human gaze control during walking over obstacles
Toigo	Skeletal muscle function and insulin sensitivity
Verrey	The mechanism and control of amino acid absorption
von Eckardstein	Metabolism, function and regulation of high density lipoproteins
Wagner	Pathways of aldosterone action in kidney and vasculature