Prof. Dr. David Nadal - Pädiatrische Infektiologiemore information

Fakultäten » Medizinische Fakultät » Kinderspital Zürich: Medizinische Klinik » Infektiologie, Abteilung » Prof. Dr. David Nadal

Current research projects

Project leader	Project title
Berger	Impact of innate immunity on susceptibility to sepsis in neonates
Nadal	In vitro production of protecting antibodies
	Is endemic Burkitt's lymphoma really promoted by chronic innate immunity triggering by malaria infection?
	Establishment of a tractable mouse model to study γ-herpesvirus-induced lymphomagenesis
	Susceptibility of memory B-cells from distinct tissues to infection and transformation by Epstein-Barr virus

Completed research projects

Project leader	Project title
Berger	The level of viral LMP2A expression (in relation to its isoform LMP2B) is critical for activation of the lytic infection program and termination of tumor-promoting EBV latency
Berger Nadal	Latent Epstein-Barr virus (EBV) infection: can cognate antigen trigger productive EBV and cause growth transformation of responding B lymphocytes?
Bernasconi	Silencing of the LMP2 gene in Epstein-Barr virus transformed B cells: induction of lytic viral cycle for tumor therapy
	Switching of latent to lytic EBV infection to specifically kill cancer cells
	Development of targeting systems for improved drug delivery and imaging of pediatric soft tissue sarcomas based on tumor specific peptides
Bonanomi Nadal	Screening, identification and characterization of host genes regulating tumor formation associated with Epstein-Barr virus
Dorner	Epstein-Barr virus is able to directly infect antigen-specific memory B cells in vivo, where it establishes life-long persistence
Nadal	Contribution of microbial stimulation of Toll-like receptor (TLR)9 to the formation of Epstein-Barr virus (EBV)-associated tumours
	Role of the innate immune system in EBV-associated lymphoma development and therapy
	Impact of the innate immunity on EBV-associated B-cell transformation and tumor formation
	Impact of specific innate immunity signal transduction pathways on the replication cycle of the Epstein-Barr virus and the murine gamma herpesvirus 68, respectively, and the importance in tumor formation
	Impact of innate immunity in the induction of Epstein-Barr virus-associated B-cell transformation and tumor formation
	Regulation of lytic Epstein-Barr virus infection by latent membrane protein (LMP)2A and LMP2B
	Functional analysis of a novel, highly efficient in vitro Epstein-Barr virus infection protocol (spinoculation) compared to the conventional protocol
	TLR9 agonist cancer therapy is rather detrimental than beneficial in EBV-harboring tumors
	The impact of conjugate heptavalent pneumococcal vaccine on improving diagnosis of invasive pneumococcal infections by detection of pneumococcal antigen in urine
	Central nervous system Epstein-Barr virus-positive post-transplant lymphoproliferative disorders in children – mechanisms of resistance to corticosteroid treatment
	The longevity enzyme hTERT facilitates attachment and entry of Epstein-Barr virus into epithelial cells
Nadal Berger Altwegg	Community-acquired pneumoniae in children
Nadal Niggli	Investigation of lymphomagenesis associated to Epstein-Barr virus infection using DNA microchip technology
Nadal Niggli Bonanomi Odermatt	Pathogenic role of cytokine gene expression in Epstein-Barr virus-associated tumor formation
Neuhaus Nadal Berger Willi	Antibiotic treatment of children with pyelonephritis
Niggli Nadal	Epstein-Barr virus (EBV) whole genome expression profiling in EBV-associated tumor formation