Current Research Projects

Project Leader Project Title
Nadal TLR9 agonist cancer therapy is rather detrimental than beneficial in EBV-harboring tumors
In vitro production of protecting antibodies
Is endemic Burkitt's lymphoma really promoted by chronic innate immunity triggering by malaria infection?
Establishment of a tractable mouse model to study γ-herpesvirus-induced lymphomagenesis

Completed Research Projects

Project Leader Project Title
Berger The level of viral LMP2A expression (in relation to its isoform LMP2B) is critical for activation of the lytic infection program and termination of tumor-promoting EBV latency
Berger Nadal Latent Epstein-Barr virus (EBV) infection: can cognate antigen trigger productive EBV and cause growth transformation of responding B lymphocytes?
Bernasconi Silencing of the LMP2 gene in Epstein-Barr virus transformed B cells: induction of lytic viral cycle for tumor therapy
Switching of latent to lytic EBV infection to specifically kill cancer cells
Development of targeting systems for improved drug delivery and imaging of pediatric soft tissue sarcomas based on tumor specific peptides
Bonanomi Nadal Screening, identification and characterization of host genes regulating tumor formation associated with Epstein-Barr virus
Dorner Epstein-Barr virus is able to directly infect antigen-specific memory B cells in vivo, where it establishes life-long persistence
Nadal Contribution of microbial stimulation of Toll-like receptor (TLR)9 to the formation of Epstein-Barr virus (EBV)-associated tumours
Role of the innate immune system in EBV-associated lymphoma development and therapy
Impact of the innate immunity on EBV-associated B-cell transformation and tumor formation
Impact of specific innate immunity signal transduction pathways on the replication cycle of the Epstein-Barr virus and the murine gamma herpesvirus 68, respectively, and the importance in tumor formation
Impact of innate immunity in the induction of Epstein-Barr virus-associated B-cell transformation and tumor formation
Regulation of lytic Epstein-Barr virus infection by latent membrane protein (LMP)2A and LMP2B
Functional analysis of a novel, highly efficient in vitro Epstein-Barr virus infection protocol (spinoculation) compared to the conventional protocol
The impact of conjugate heptavalent pneumococcal vaccine on improving diagnosis of invasive pneumococcal infections by detection of pneumococcal antigen in urine
Central nervous system Epstein-Barr virus-positive post-transplant lymphoproliferative disorders in children – mechanisms of resistance to corticosteroid treatment
Nadal Berger Altwegg Community-acquired pneumoniae in children
Nadal Niggli Investigation of lymphomagenesis associated to Epstein-Barr virus infection using DNA microchip technology
Nadal Niggli Bonanomi Odermatt Pathogenic role of cytokine gene expression in Epstein-Barr virus-associated tumor formation
Neuhaus Nadal Berger Willi Antibiotic treatment of children with pyelonephritis
Niggli Nadal Epstein-Barr virus (EBV) whole genome expression profiling in EBV-associated tumor formation

© Universität Zürich, 1. Juni 2010, Impressum