Prof. Dr. Felix Niggli

Fakultäten » Medizinische Fakultät » Kinderspital Zürich: Medizinische Klinik » Onkologie, Abteilung » Prof. Dr. Felix Niggli

Current research projects

Project leader	Project title
Niggli	Constitution of a national study centre for the European acute lymphoblastic leukaemia trial (AIEOP-BFM ALL 2009) on behalf of the Swiss paediatric oncology group (BFM-CH)
Niggli Schäfer	Upstream of EWS/FLI1 - opportunities for novel therapeutic interventions
Schäfer	Molecular mechanisms underlying the pathogenesis of rhabdomyosarcoma: regulating oncogenic transcription factor activity
	Molecular mechanisms underlying the pathogenesis of rhabdomyosarcoma: cancer stem cells as therapeutic target
	Primary xenograft (tumorgraft) model of childhood sarcoma as tool to prioritize novel drugs for further clinical development

Completed research projects

Project leader	Project title
Arcaro	Cancer and Cell Biology
	Identification of new molecular targets for human medulloblastoma using RNA interference screening
	Signalling by class II phosphoinositide 3-kinases downstream of receptor tyrosine kinases
Bernasconi	A Molecular ZIP Code for Vascular Targeting of Pediatric Embryonal Tumors
Grotzer	Inhibition of Insulin-like Growth Factor I Receptor Signaling in Pediatric Teratoid/Rhabdoid CNS Tumors
	Novel Therapeutic Approaches for Central Nervous System Primitive Neuroectodermal Tumors of Childhood
	Neurotrophin-Receptors and Oncogene MYC in Central Nervous System Primitive Neuroectodermal Tumors of Childhood
	Central Tumor Bank für Children’s Malignant Tumors of the Swiss Pediatric Oncology Group (SPOG)
Nadal Niggli	Investigation of lymphomagenesis associated to Epstein-Barr virus infection using DNA microchip technology
Niggli	Establishing of minimal residual disease techniques in childhood acute lymphoblastic leukemia and their application in an international clinical treatment trial
	Generation of a Wilms tumor mouse model: role of wnt signaling
Niggli Nadal	Epstein-Barr Virus (EBV) Whole Genome Expression profiling in EBV-associated Lymphomas: Development of an Oligonucleotide Microarray and Applications.
Niggli Schäfer	Innovative treatment approaches for Ewing's sarcoma
Schäfer	Molecular basis of sarcoma tumor development
	Oncogenic fusion proteins as therapeutic targets in pediatric sarcomas
	Subclass prediction in paediatric acute lymphoblastic leukaemia using gene expression profiling