Knirsch
Fakultäten » Medizinische Fakultät » Kinderspital Zürich: Medizinische Klinik » Kardiologie, Abteilung » Prof. Dr. Urs Bauersfeld (verstorben) » Knirsch
Completed research project
| Title / Titel | The role of brain natriuretic peptide in patients with congenital heart disease | ||
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| Abstract (PDF, 14 KB) | |||
| Original title / Originaltitel | Die Bedeutung von Brain Natriuretic Peptide bei Patienten mit angeborenen Herzfehlern | ||
| Summary / Zusammenfassung | Brain natriuretic peptide (BNP) is a polypeptide secreted by the ventricles of the human heart in response to stretching of myocytes. The physiologic action of BNP include increase of natriuresis, decrease of systemic vascular resistance and central venous pressure, resulting in an increase of cardiac output. Elevated levels of BNP are measured in adult and pediatric patients suffering from congestive heart failure. The aim of the study is to analyse the role of BNP in pediatric patients with different types of congenital heart defects. Therefore, we will perform data analysis of levels of BNP in patients with CHD before invasive procedures, i.e. cardiac surgery respectively cardiac catheter interventions performed in our institution. Subgroup analysis for different hemodynamics (volume vs. pressure overload of the ventricle) will be done. |
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| Publications / Publikationen | Gessler P, Knirsch W, Schmitt B, Rousson V, von Eckardstein A (2006) Prognostic value of plasma N-terminal pro- brain natriuretic peptide in children with congenital heart defects and open-heart surgery. J Pediatr 148:372-376Dodge-Khatami A, Valsangiacomo Büchel E, Knirsch W, Kadner A, Rousson V, Dave H, Bauersfeld U, Pretre R (2006) Brain Natriuretic Peptide and Magnetic Resonance Imaging in Tetralogy With Right Ventricular Dilatation. Ann Thorac Surg 82:983-988 |
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| Keywords / Suchbegriffe | Brain natriuretic peptide, heart failure, children, congenital heart defect | ||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
No project-specific funding |
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| Duration of Project / Projektdauer | Jan 2008 to Dec 2009 |