Albisetti
Fakultäten » Medizinische Fakultät » Kinderspital Zürich: Medizinische Klinik » Hämatologie, Abteilung » PD Dr. Markus Schmugge Liner » Albisetti
Completed research project
| Title / Titel | Aspirin resistance in children after interventional cardiac catheterization | ||||||
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| Abstract (PDF, 14 KB) | |||||||
| Summary / Zusammenfassung | During the last 20 years, several large trials have consistently demonstrated the absolute benefit of aspirin in the prevention of arterial thrombotic events in adults. However, recurrent thromboembolic events have been reported in 5 to 45% of adult patients despite treatment with aspirin, a phenomenon that has been called “aspirin resistance”. Thus, the term “aspirin resistance” has been primarily used to describe the clinical inability of aspirin to protect individuals from arterial thrombotic events. This definition is not specific and may reflect treatment failure rather than resistance to aspirin, particularly why this definition may apply to several conditions such as poor compliance or inadequate doses possibly causing recurrent vascular events despite aspirin intake. Thus, the term “aspirin resistance” has evolved to define the failure of aspirin to produce an expected response on one or more laboratory measures of platelet activation and aggregation. Although aspirin is increasingly administered to children to treat arterial ischemic stroke and prevent thromboembolic events following several cardiac catheterization procedures, no published data regarding aspirin resistance in children is available. We are currently studying the prevalence of aspirin resistance in a well-defined population of children undergoing interventional cardiac catheterization. Weitere Informationen |
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| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
Foundation |
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| Duration of Project / Projektdauer | Feb 2006 to Dec 2010 |