Böker
Fakultäten » Medizinische Fakultät » Psychiatrische Universitätsklinik » Affektive Erkrankungen und Allgemeinpsychiatrie Zürich Ost, Klinik für » Prof. Dr. Erich Seifritz » Böker
Current research project
| Title / Titel | Neural and metabolic correlates of emotional processing in major depressive disorder - A multimodal imaging study during pharmacological intervention with ketamine. | ||||||||
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| Abstract (PDF, 14 KB) | |||||||||
| Summary / Zusammenfassung | Ketamine is a potent NMDA receptor antagonist with rapid antidepressant properties at subanaesthetic doses, thus providing a valuable research tool for the investigation of the neurobiology of the glutamatergic system in major depressive disorder (MDD). This multimodal imaging study aims at investigating the effects of a subanaesthetic ketamine infusion on fMRI-BOLD responses during an emotional processing task and their relationship to glutamatergic metabolite concentrations in the pregenual anterior cingulate cortex (PACC) assessed by proton magnetic resonance spectroscopy (1H-MRS). The study advances the understanding of the neural and metabolic effects of ketamine on emotional processing and glutamatergic metabolism and thus provides a basis for further investigation of the antidepressant properties of NMDA-receptor antagonism in major depressive disorder. The project will reveal pharmacological effects on 1) fMRI-BOLD responses under cognitive and emotional stimulation, 2) resting state functional connectivity (rsfMRI), 3) cerebral blood flow (Arterial Spin Labeling, ASL) and 4) metabolite concentrations in the prefrontal cortex (1H-MRS) during intervention with Sketamine compared to baseline conditions. This multimodal approach using fMRI, ASL, and MRS will be applied in both healthy and MDD subjects in order to understand the mechanisms associated with the antidepressant effects of ketamine and to identify clinically relevant biomarkers that predict treatment response. |
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| Keywords / Suchbegriffe | ASL, fMRI, MRS, Major Depression, Ketamine. | ||||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
Universität Zürich (position pursuing an academic career) |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | Apr 2009 to Apr 2012 |