Maurer

Fakultäten » Medizinische Fakultät » Anästhesiologie, Institut für » Dr. Konrad Maurer » Maurer

Completed research project

Title / Titel	Effect of local buprenorphine on ulnar nerve motor block
PDF	Abstract (PDF, 14 KB)
Summary / Zusammenfassung	The partial opioid-receptor (OR) agonist buprenorphine is used clinically for the treatment of severe acute and chronic pain states such as postoperative or neuropathic pain. Buprenorphine not only exerts a strong antinociception, but also a long lasting antihyperalgesic effect. This antihyperalgesic effect is not observed for other clinically employed opioids but is common for local anaesthetics. In the present study we like to demonstrate that buprenorphine displays common features of local anaesthetics additional to its known OR-mediated antinociceptive effect. The principal aim of the study is to measure the speed of onset and the time of recovery of motor blockage achieved by lidocaine and buprenorphine, respectively, measured with threshold tracking techniques.
Project leadership and contacts / Projektleitung und Kontakte	Dr. Konrad Maurer, MD (Project Leader) konrad.maurer@usz.ch Dr. Patrick Willimann, MD patrick.willimann@usz.ch Dr. Manuel Coradi, MD manuel.coradi@usz.ch Prof. Donat Spahn, MD donat.spahn@usz.ch
Funding source(s) / Unterstützt durch	No project-specific funding
Duration of Project / Projektdauer	May 2009 to Aug 2011