Moeller
Fakultäten » Medizinische Fakultät » Kinderspital Zürich: Medizinische Klinik » Pneumologie » PD Dr. Alexander Möller » Moeller
Completed research project
| Title / Titel | Respiratory muscle endurance training (RMET) in children and adolescents with cystic fibrosis | ||||||||
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| Abstract (PDF, 14 KB) | |||||||||
| Original title / Originaltitel | Ausdauertraining der Atemmuskulatur bei Kindern und Jugendlichen mit cystischer Fibrose |
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| Summary / Zusammenfassung | Background: RMET has been shown to increase endurance performance in healthy subjects and patients with different neurological diseases such as spinal cord injury and myasthenia gravis. In adult COPD patients RMET resulted in increased inspiratory muscle strength and endurance, improvement of outcomes of exercise capacity and on measures of quality of life, and decreased dyspnea. Two studies have been performed so far in patients with cystic fibrosis. RMET resulted in improved lung function in both studies, reduced antibiotic use in one and increased sputum production in the other study. Whereas the study by Sartori et al. did not include a control group, the study by Kamin et al. was of a cross-over design but changed the training between the two study periods. Aims: To investigate the effects of eight weeks of RMET in children and adolescents with CF on quality of life, exercise endurance, respiratory muscle endurance, lung function and symptoms. Methods: Patients aged between 7 and 18 years will be randomized to two groups. Group A will perform 8 weeks of RMET using a specific training device (SpioTiger) followed by 8 weeks of normal CF-specific chest physiotherapy (control period). Group B will begin with the control period and switch to RMET after 8 weeks. Assessments include lung function, respiratory endurance, quality of life (CFQ), symptom scores and a constant wok load exercise test at visit 1, 2 and 3 each eight weeks apart. Hypotheses: For primary outcomes: eight weeks of RMET will lead to improved exercise endurance measured by a constant work load test and increase respiratory endurance; in addition quality of life improves due to improved ventilatory limitation and dyspnea. Secondary outcomes include lung function (spirometry and body plethysmography) and clinical scores (Kanga score). |
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| Keywords / Suchbegriffe | cystic fibrosis, children, respiratory muscle traning, spirotiger, exercise | ||||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
Private Sector (e.g. Industry), Others |
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| Duration of Project / Projektdauer | Dec 2008 to Mar 2011 |