Assessment of regional myocardial function by using CMR

Completed Research Project

Summary / Zusammenfassung: Evaluation of regional myocardial function adds important information to global ventricular function and might be considered an advanced tool for evaluation of ventricular performance. There is some evidence that regional myocardial function may be affected earlier than global ventricular function in the presence of cardiac dysfunction. Cardiac desynchronization, i.e. delayed activation and dynamics of different regional segments, is therefore a frequent finding in patient with cardiac failure, occurring in up to 50% of the patients. Desynchronization is considered a marker for an impaired prognosis. Selection criteria for cardiac resynchronisation therapy have been defined on the base of clinical and echocardiographic findings. Nevertheless approximately 30% of the treated patients are non-responder, so that advanced methods for assessment of mechanical assynchrony by non-invasive imaging are still required. Beside echocardiographic techniques, including flow Doppler measurements, Tissue Doppler imaging, 2D strain (rate) and 3D echocardiography, some CMR sequences have been described. Myocardial tagging, myocardial tissue phase mapping and CMR strain have been developed and their application has been tested /validated in animals and adult volunteers . The aim of this project is to develop and validate a CMR sequence (GE scanner) to assess regional myocardial function in a clinical setting, in patients with congenital

Keywords / Suchbegriffe: Tissue phase mapping, cardiac desynchronization, mechanical asynchrony, congenital heart disease.

Project Leadership and Contacts / Projektleitung und Kontakte

Dr. Clare Jackson, PhD (Project Leader)	Clare.Jackson@kispi.uzh.ch
Dr. Emanuela Valsangiacomo-Büchel, MD (Project Leader)	Emanuela.Valsangiacomo@kispi.uzh.ch
Dr. Christian Kellenberger, MD (Project Leader)	Christian.Kellenberger@kispi.uzh.ch
Prof. Dr. Urs Bauersfeld, MD (Project Leader)	Urs.Bauersfeld@kispi.uzh.ch

Funding Source(s) / Unterstützt durch: Others
Georg und Bertha Schwyzer-Winiker Stiftung

In Collaboration with / In Zusammenarbeit mit

Matthew Robson PhD, University of Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, UK	United Kingdom
Michael Markl, PD MD, Department of Diagnostic Radiology, Medical Physics University Hospital Freiburg, Germany	Germany