Beck Schimmer
Fakultäten » Medizinische Fakultät » Anästhesiologie, Institut für » Prof. Dr. Beatrice Beck Schimmer » Beck Schimmer
Completed research project
| Title / Titel | Role of epithelial adhesion molecules in the endotoxin-, acid- and hypoxia-induced lung injury | ||||
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| Abstract (PDF, 14 KB) | |||||
| Summary / Zusammenfassung | Adhesion molecules play an important role in the recruitment of leukocytes to sites of tissue injury. The adhesive interactions between leukocytes and endothelial cells, mediated by adhesion molecules, have been studied intensively during the past years. The mechanisms of leukocyte-epithelial adhesion however are still unknown. The purpose of the present proposal is therefore to examine the mechanism and the pathogenic significance of the altered adhesion molecule expression in the respiratory tract of rat lung in various pulmonary injury processes, focusing primarily on epithelial cells in the respiratory compartment. In addition, the functional role of adhesion molecules on respiratory epithelial cells will be explored in human lung injury. | ||||
| Publications / Publikationen | Madjdpour C, Jewell UR, Kneller S, Ziegler U, Schwendener R, Booy C, Pasch T, Schimmer RC, Beck-Schimmer B (2003) Decreased alveolar oxygen induces lung inflammation Am J Physiol, 284, L360-L367Beck-Schimmer B, Madjdpour C, Kneller S, Ziegler U, Pasch T, Wuethrich RP, Ward PA, Schimmer RC (2002 Role of alveolar epithelial ICAM-1 in lipopolysaccharide-induced lung inflammation Eur Respir J 19 (6), 1-9Beck-Schimmer B, Schimmer RC, Madjdpour C, Bonvini JM, Pasch T, Ward PA (2001 Hypoxia mediates increased neutrophil and macrophage adhesiveness to alveolar epithelial cells Am J Resp Cell Mol Biol 25, 780-787 |
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| Keywords / Suchbegriffe | Immunology, Immunopathology | ||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
SNF (Personen- und Projektförderung) |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | Apr 1999 to Jun 2003 |