Csomor

Fakultäten » Medizinische Fakultät » Psychiatrische Universitätsklinik » Affektive Erkrankungen und Allgemeinpsychiatrie Zürich Ost, Klinik für » Prof. Dr. Erich Seifritz » Csomor

Completed research project

Title / Titel	Impact of neurochemical manipulation on sensory gating in healthy subjects with low gating levels: validation of a translational model
PDF	Abstract (PDF, 14 KB)
Summary / Zusammenfassung	Translational models in humans based on biomarkers offer the potential to bridge the gap between drug discovery in animals and development in humans. We have recently developed an approach to investigate the possible differential effects of antipsychotic medication on prepulse inhibition (PPI) and P50 suppression in healthy subjects exhibiting either high or low levels of gating, rather than in patients. The aim of the current study is to validate our translational model using three antipsychotics (aripiprazole, risperidone, amisulpride), and three non-antipsychotics (lorazepam, modafinil, valproate) which served as negative control treatments.
Publications / Publikationen	Csomor,P.A. & Vollenweider,F.X. Impact of Neurochemical Manipulation on Sensory Gating in Healthy Subjects with Low Gating Levels. Schizophr. Bull. 35, 59 (2009).
Keywords / Suchbegriffe	prepulse inhibition, P50 suppression, startle, gating, antipsychotics, human, translational medicine
Project leadership and contacts / Projektleitung und Kontakte	Dr. sc. ETH Philipp Csomor, PhD (Project Leader) csomor@bli.uzh.ch Prof. Dr. Franz Vollenweider vollen@bli.uzh.ch
Funding source(s) / Unterstützt durch	Others
In collaboration with / In Zusammenarbeit mit	AstraZeneca United States
Duration of Project / Projektdauer	Nov 2007 to May 2010