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Quednow

Fakultäten » Medizinische Fakultät » Psychiatrische Universitätsklinik » Affektive Erkrankungen und Allgemeinpsychiatrie Zürich Ost, Klinik für » Prof. Dr. Erich Seifritz » Quednow

Current research project

Title / Titel Genetics of sensorimotor gating in schizophrenia in healthy humans
PDF Abstract (PDF, 14 KB)
Summary / Zusammenfassung Attentional gating deficits, commonly measured by prepulse inhibition (PPI) of the acoustic startle response (ASR), have been established as an endophenotype of schizophrenia. PPI is heritable and has been associated with polymorphisms in serotonin and dopamine system genes. The aim of the study is to further elucidate the genetic basis of sensorimotor gating to better understand the genetic influences on schizophrenia.
Publications / Publikationen Petrovsky N*, Quednow BB*, Schmechtig A, Mössner R, Ettinger U, Collier DA, Kühn KU, Maier W, Wagner M, Kumari V (2009). Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers. Neuropsychopharmacology. In press.

Quednow BB, Kühn KU, Maier W, Mössner R, Schwab SG, Wagner M (2008). Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphisms. Biol Psychiatry 64: 434-437.

Quednow BB, Wagner M, Mössner R, Maier W, Kühn KU (2009). Sensorimotor gating of schizophrenia patients depends on catechol O-methyltransferase Val158Met polymorphism. Schizophr Bull. In press.

Quednow BB, Schmechtig A, Ettinger U, Petrovsky N, Collier DA, Vollenweider FX, Wagner M, Kumari V (2009). Sensorimotor gating depends on polymorphisms of the 5-HT2A receptor and COMT, but not on neuregulin-1 Arg38Gln genotype: a replication study. Biol Psychiatry. In press.
Keywords / Suchbegriffe SNP, genetics, gene, serotonin, dopamin, gating, PPI, startle, schizophrenia endophenotype, acetylcholine
Project leadership and contacts /
Projektleitung und Kontakte
Prof. Dr. Boris Quednow (Project Leader) quednow@bli.uzh.ch
Funding source(s) /
Unterstützt durch		 Private Sector (e.g. Industry), Others
 
In collaboration with /
In Zusammenarbeit mit
Prof. Dr. Michael Wagner, Department of Psychiatry and Psychotherapy, University of Bonn

Dr. Ulrich Ettinger, Department of Psychiatry and Department of Psychology, Ludwig-Maximilians University Munich		 Germany

Prof. Dr. Veena Kumari, Department of Psychology, Institute of Psychiatry, King's College London, London, United Kingdom

United Kingdom
Duration of Project / Projektdauer Jan 2008 to Dec 2012
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