Stassen
Fakultäten » Medizinische Fakultät » Psychiatrische Universitätsklinik » Affektive Erkrankungen und Allgemeinpsychiatrie Zürich Ost, Klinik für » Prof. Dr. Erich Seifritz » Stassen
Current research project
| Title / Titel | Activation of inflammatory response system in depression and schizophrenia | ||||||
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| Abstract (PDF, 14 KB) | |||||||
| Summary / Zusammenfassung | A genetically predisposed aberrancy of the inflammatory response system has been linked to various complex diseases. Evidence for an involvement in the pathogenesis of psychiatric disorders includes: (1) a population-based study of 7,704 patients with a diagnosis of schizophrenia and 192,590 control subjects without psychiatric history which revealed that a parental history of schizophrenia was associated with a 5-fold risk for autoimmune diseases, whereas a parental history of autoimmune diseases increased this risk only slightly, by a factor of 1.45; (2) several antidepressants and antipsychotics show anti-inflammatory effects; and (3) a quantitative (R)-[11C]PK11195 positron emission tomography study demonstrated microglia activation in recent-onset schizophrenia. Investigations into the time course of improvement in patients under antidepressants (n=516) and antipsychotics (n=267) suggested that up to 15% of the observed variation of response under antidepressants and up to 25% under antipsychotics might be explainable through anti-inflammatory effects. (Supported in part by a grant of the Swiss National Science Foundation) Weitere Informationen |
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| Publications / Publikationen | Stassen HH, Szegedi A, Scharfetter C: Modeling Activation of Inflammatory Response System. A Molecular-Genetic Neural Network Analysis. BMC Proceedings 2007, 1 (Suppl 1): S61, 1-6Stassen HH, Hoffmann K, Scharfetter C: The Difficulties of Reproducing Conventionally Derived Results through 500k-Chip Technology. BMC Genet Proc. 2009;3 Suppl 7: S66Weitere Informationen | ||||||
| Keywords / Suchbegriffe | Inflammatory reactions, genetic modulation, neural network analysis, SNPs, multidimensional | ||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
SNF (Personen- und Projektförderung) |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | Apr 2008 to Apr 2012 |