Fritschy
Fakultäten » Medizinische Fakultät » Neurologie, Klinik für » Prof. Dr. Heinz-Gregor Wieser (emeritiert) » Fritschy
Completed research project
| Title / Titel | Plasticity of GABAergic synapses: cellular mechanisms in vitro and significance for temporal lobe epilepsy | ||||||||
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| Abstract (PDF, 14 KB) | |||||||||
| Summary / Zusammenfassung | Temporal lobe epilepsy (TLE) is associated with impaired inhibitory neurotransmission. Studies in animal models suggest that GABA(A) receptor dysfunction contributes to epileptogenesis. To understand the mechanisms underlying TLE in humans, it is fundamental to determine whether and how GABA(A) receptor subtypes are altered. Furthermore, identifying novel receptor targets is a prerequisite for developing selective antiepileptic drugs. We have therefore analyzed subunit composition and distribution of the three major GABA(A) receptor subtypes immunohistochemically with subunit-specific antibodies (alpha1, alpha2, alpha3, beta2,3, and gamma2) in surgical specimens from TLE patients with hippocampal sclerosis. In previous studies, profound alterations in GABA(A) receptor subtype expression were observed when compared with control hippocampi. | ||||||||
| Publications / Publikationen | Loup F, Wieser HG, Yonekawa Y, Aguzzi A, Fritschy JM. Selective alterations in GABAA receptor subtypes in human temporal lobe epilepsy. J Neurosci 2000 Jul 15;20(14):5401-19Fritschy JM, Kiener T, Bouilleret V, Loup F. GABAergic neurons and GABA(A)-receptors in temporal lobe epilepsy. Neurochem Int 1999 May;34(5):435-45Loup F, Weinmann O, Yonekawa Y, Aguzzi A, Wieser HG, Fritschy JM. A highly sensitive immunofluorescence procedure for analyzing the subcellular distribution of GABAA receptor subunits in the human brain. J Histochem Cytochem 1998 Oct;46(10):1129-39 | ||||||||
| Keywords / Suchbegriffe | GABA-A, temporal lobe epilepsy, hippocampus, subunit | ||||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
SNF (Personen- und Projektförderung), SNF (Programm NFS/NCCR) SNF (Project 3100-063901) |
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| Duration of Project / Projektdauer | Jan 2002 to Dec 2004 |