Buck
Fakultäten » Medizinische Fakultät » Neurologie, Klinik für » Prof. Dr. Heinz-Gregor Wieser (emeritiert) » Buck
Completed research project
| Title / Titel | Assessment of hippocampal function with (O-15)H2O-PET, fMRI and cognitive evoked potentials with regard to predicting memory deficits. | ||||||
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| Abstract (PDF, 14 KB) | |||||||
| Summary / Zusammenfassung | The hippocampal formation plays an important function in the formation of the episodic and semantic memory and bilateral damage results in severe memory disturbances. Therefore, in patients suffering from drug resistant mesial temporal lobe epilepsy the functional integrity of the epileptogenic and non-epileptogenic hippocampus has to be assessed to before the epileptogenic hippocampus can be resected. For this purpose a intracarotidal or intrachoroidal amobarbital test (WADA-test) test is traditionally used. The aim of this project is to develop a non-invasive test using PET and/or fMRI in combination with a neuropsychological test procedure designed to selectively activate the hippocampal formation . | ||||||
| Publications / Publikationen | Henke K, Weber B, Kneifel S, Wieser HG, Buck A. Human hippocampus associates information in memory. Proc Natl Acad Sci U S A 1999 May 11;96(10):5884-9Henke K, Buck A, Weber B, Wieser HG. Human hippocampus establishes associations in memory. Hippocampus 1997;7(3):249-56Wieser HG, Müller S, Schiess R, Khan N, Regard M,Landis T, Bjeljac M, Buck A, Valavanis A, Yasargil G, Yonekawa Y. The anterior and posterior selective temporal lobe amobarbital tests: angiographical, clinical, electroencephalographical PET and SPECT findings, and memory performance. Brain Cogn 1997; 33:71-97: | ||||||
| Keywords / Suchbegriffe | hippocampus, epilepsy, memory, PET, fMRI | ||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
SNF (Personen- und Projektförderung) SNF (Project Number : 3100-047203) |
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| Duration of Project / Projektdauer | Jun 1997 to Aug 1999 |