Sydler Brugnera Sidler
Fakultäten » Vetsuisse-Fakultät » Nutztiere, Departement für » Schweinemedizin, Abteilung für » Dr. Xaver Sidler » Sydler Brugnera Sidler
Current research project
| Title / Titel | Is PCV2 virulence the main factor for triggering the PMWS epizooty? | ||||||||
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| Abstract (PDF, 14 KB) | |||||||||
| Original title / Originaltitel | Ist eine erhöhte PCV2 Virulenz der ausschlaggebenede Faktor bei der Auslösung der PMWS Epizootie? | ||||||||
| Summary / Zusammenfassung | Postweaning multisystemic and wasting syndrome (PMWS) is regarded as a major economical problem in pig production and a concern in pig welfare. Also, the presence of Porcine Circovirus type-2 (PCV2) is indis-pensable in PMWS diagnosis. PCV2 tenacity is high and therefore may be transmitted without animal-to-animal contact. Another aspect is PCV2 viruses’ high genomic plasticity. PCV2 in pig tissue was already identified in 1979, however, it was not until the end of 2003 for PMWS epizooty outbreak. With it a new distinct sub-genotype group within the PCV2b genotypes was found, which we named PCV2b-CH. Parallel to our observation other research groups also found a shift to PCV2b genotypes. Remarkably, several recent reports imply the pig specific pathogenic PCV2b genotype with bovine infections and PCV2b may even cause disease in the “foreign” host. Nevertheless, the question remains whether PMWS disease would be dependant on a cofactor in addi-tion to PCV2. The answer to this critical question is central to future in vivo diagnostic and surveillance. The goal of this study is to reconstruct PCV2a and the putative pathogenic PCV2b-CH viruses’ from paraffin embedded tissue blocks and use mixed PCV2 viruses’ cocktails for an animal infection model to test virus pathogenicity. |
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| Keywords / Suchbegriffe | PCV2, PMWS, animal infection model, genetic drift, surveillance, pig | ||||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
Other Public Sources (e.g. Federal or Cantonal Agencies) |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | Jan 2010 to Dec 2012 |