Hornemann
Fakultäten » Medizinische Fakultät » Zentrum für Integrative Humanphysiologie (ZIHP) » ZIHP Zürcher Zentrum für Integrative Humanphysiologie » Hornemann
Current research project
| Title / Titel | The role of deoxy-sphingoid bases in diabetes mellitus and the diabetic sensory neuropathy | ||||||||
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| Abstract (PDF, 14 KB) | |||||||||
| Summary / Zusammenfassung | Deoxy-sphingobases (DSB) are atypical sphingolipid metabolites which are formed as by-products by the enzyme serine-palmitoyltransferase. Pathologically elevated DSB levels are the cause for the hereditary sensory neuropathy type 1 (HSAN1). Elevated DSB levels are also found in plasma of patients with metabolic syndrome and diabetes. This project aims to investigate the molecular mechanisms by which the DSBs act neurotoxically and their contribution to the pathology of diabetes and diabetic neuropathy. Furthermore, using chemical, molecular and biochemical analyses of human and animal models we want to explore the potential use of DSBs as a prospective plasma biomarker in such diseases. | ||||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Other links to external web pages | http://www.zihp.uzh.ch/1610.php#44 | ||||||||
| Funding source(s) / Unterstützt durch |
Others This project is primarily supported by the University Research Priority Program "Integrative Human Physiology" at the University of Zurich. |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | Jan 2011 to Dec 2012 |