Mölling

Fakultäten » Medizinische Fakultät » Medizinische Virologie, Institut für » Prof. Dr. Karin Mölling (emeritiert) » Mölling

Completed research project

Title / Titel	Signaling via PDZ Domains
PDF	Abstract (PDF, 14 KB)
Summary / Zusammenfassung	The yeast two-hybrid system allowed the identification of PDZ protein binding to various receptors involved in signaling, neuronal pathfinding, angiogenesis, etc., which was published in Nature Biotechnology (1999). Since then PDZ domains have become a focus of research. The results demonstrate that PDZ domains play a major role in the maintenance of a non-proliferative state of cells. They interact with the very C-terminal aminoacids of receptor tyrosine kinases. Several oncoprotein-PDZ protein interactions are under investigation. The PDZ protein AF-6, called canoe or dorsal closure defect in other organisms, which contributes to the human genetic defect cleft lip syndrome, is important at tight-junctions for cell-cell-contact. It negatively regulates the Raf kinase pathway for the maintenance of a non-proliferative state. Knockdown by siRNA results in severe cellular changes and prevent spread of viruses. Also the protein Erbin is a PDZ protein under investigation for a number of interaction partners. A collaboration with the Charité and Max-Dellbrück-Center in Berlin focuses on peptide ligands interacting with PDZ proteins to characterize the relevant aminoacids as well as regulatory effects.
Keywords / Suchbegriffe	Neurosciences, Tumor Research
Project leadership and contacts / Projektleitung und Kontakte	Prof. Karin Mölling (Project Leader) moelling@immv.uzh.ch
Funding source(s) / Unterstützt durch	SNF (Personen- und Projektförderung), Others
In collaboration with / In Zusammenarbeit mit	Charité, Berlin Max-Dellbrück Center, Berlin Germany
Duration of Project / Projektdauer	Jan 1997 to Jan 2008