Dennler Feige

Fakultäten » Vetsuisse-Fakultät » Nutztiere, Departement für » Wiederkäuer, Klinik für » Prof. Dr. Ueli Braun » Dennler Feige

Completed research project

Title / Titel	Investigations on the applicability of recombinant hirudin in horses
PDF	Abstract (PDF, 14 KB)
Original title / Originaltitel	Untersuchungen zur Anwendbarkeit von rekombinantem Hirudin beim Pferd
Summary / Zusammenfassung	Hirudin is a potent thrombin-specific inhibitor that forms equimolar complexes with thrombin. It represents a new anticoagulant agent in a field in which heparin has been the only available drug for many years. In contrast to heparin, hirudin does not require antithrombin III as a cofactor, is not inactivated by antiheparin proteins, has no direct effects on platelets, and additionally is able to inactivate thrombin bound to clots or the subendothelium. The aim of this investigation is the evaluation of the prophylactic and therapeutic use of recombinant hirudin in coagulation disorders in horses and to work out pharmacocinetic data for further clinical stuies.
Keywords / Suchbegriffe	Pferd, Hirudin, pharmakokinetische Daten, Dissertation, Heparin, Antithrombin III
Project leadership and contacts / Projektleitung und Kontakte	med. vet. M. Dennler (Project Leader) mdennler@vetklinik.uzh.ch Dr. med. vet. K. Feige (Project Leader) kfeige@vetklinik.uzh.ch Prof. Dr. med. vet. U. Braun ubraun@vetklinik.uzh.ch
Funding source(s) / Unterstützt durch	Universität Zürich (position pursuing an academic career)
In collaboration with / In Zusammenarbeit mit	Institut für Veterinärpharmakologie und -toxikologie Switzerland Kantonsspital Aarau, Gerinnungslabor Switzerland
Duration of Project / Projektdauer	May 1999 to May 2001