Beck Schimmer
Fakultäten » Medizinische Fakultät » Anästhesiologie, Institut für » Prof. Dr. Beatrice Beck Schimmer » Beck Schimmer
Completed research project
| Title / Titel | Role of alveolar macrophages and neutrophils in the endotoxin-, aspiration- and hypoxia-induced lung injury | ||||
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| Abstract (PDF, 14 KB) | |||||
| Summary / Zusammenfassung | The airway epithelium is a physiological barrier to a variety of environmental agents including gases, particulates and microbes. An injury to lung tissue can lead to serious illness and life-threatening conditions. After an initial lesion to the lung, regulatory mechanisms start as an inflammatory response, which can be both injurious and repairing. During the development of acute inflammatory lung injury, alveolar macrophages posses a very important role, when they become activated and release cytokines and chemokines. Neutrophils are recruited and activated through theses mediators. They are of crucial importance in host defense, but are also involved in tissue damage. In order to study the role and function of alveolar macrophages, a very useful experimental system will make use of alveolar macrophage depletion in vivo. The depletion of macfopahges is based on accumulation of dichloromethylene diphosphonate-liposomes (clodronate-liposomes) as phagolysozymes. Phagocytosis of the liposomes results in selective destruction of the macrophages. Systemic depletion of neutrophilic cells can be achieved by application of an anti-neutrophil antibody intravensously prior to the induction of lung injury. Experiments are performed using three different well-established lung inflammatory models: endotoxin-, acid- and hypoxia-induced lung injury. The three models represent common clinical situations. These studies will provide new insights into exact mechanisms of epithelial cell injury by evaluating the role of phagocytes in the respiratory compartment in tissue injury. Therefore, novel therapeutic strategies might be developed based on these informations. |
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| Publications / Publikationen | Madjdpour C, Jewell UR, Kneller S, Ziegler U, Schwendener R, Booy C, Pasch T, Schimmer RC, Beck-Schimmer B (2003) Decreased alveolar oxygen induces lung inflammation Am J Physiol, 284, L360-L367 |
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| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
Foundation Gebert Rüf Stiftung |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | Nov 2001 to Jul 2003 |