Heizmann
Fakultäten » Medizinische Fakultät » Kinderspital Zürich: Medizinische Klinik » Klinische Chemie und Biochemie, Abteilung für » PD Dr. Martin Hersberger » Heizmann
Current research project
| Title / Titel | Calcium signaling in health and disease. | ||
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| Abstract (PDF, 14 KB) | |||
| Summary / Zusammenfassung | Calcium regulates a large number of biological processes, including motility, synthesis and release of neurotransmitters, differentiation, cell division, and apoptosis. Impairment of calcium homeostasis or calcium signaling is implicated in a number of human diseases, including cardiomyopathies, cancer, and neurodegenerative disorders. The calcium signal is transmitted via a large number of calcium-binding proteins characterized by a common structural motif, the EF-hand. More than 200 members of this family are now known, including the largest subfamily of S100 proteins. Today, more than 20 S100 proteins are described with distinct pleiotropic intra- and extracellular functions. We investigate the gene and protein structures of S100 proteins, their interactions with the extracellular receptor RAGE (Receptor for Advanced Glycation End Products), explore their physiological functions, examine their potential use in diagnostics, and we would like to determine whether these proteins and the pathways in which they function may serve as sites for drug interventions. | ||
| Publications / Publikationen | The importance of Ca2+/Zn2+-signaling S100 proteins and their receptor RAGE In translational medicine: impact on diagnostics and therapy in human disorders. E.Leclerc and C.W.Heizmann. Frontiers Biosci.S3, 1232-1262 (2011)S100 and S100 fused-type protein families in epidermal maturation with specific focus on S100A3 in mammalian hair cuticles. K.Kizawa, H.Takahara,M Unno and C.W. Heizmann. BIOCHIMIE 93, 2038-2047 (2011)Biochim.Biophys Acta Mol.Cell Res. Special Issue: 11th European Symposium on Calcium. (J.Haiech, C.W.Heizmann and J.Krebs eds.) Vol 1813 (2011)Refined crystal structures of human Ca2+/Zn2+-binding S100A3 protein characterized by two disulphide bridges. M.Unno, T.Kawasaki, H.Takahara, C.W.Heizmann and K.Kizawa. J.Mol.Biol 408,477-490 (2011) with suppl. dataMitochondrial matrix calcium is an activating signal for hormone secretion. A.Wiederkehr, G.Szanda, D.Akhmedov, C.Mataki, C.W.Heizmann, K Schoonjans, T.Pozzan, A.Spät and C.B.Wollheim. Cell Metabolism 13,601-611 (2011)The surprising composition of the human pre-term newborn salivary proteome. M.Castagnola, R.Inzitari,C.Fanali, F.Iavarone, A.Vitali, C.Desidero, G.Vento, C.Tirone, C.Romagnoli, T.Cabras,B.Manconi,M.T.Sana,R.Boi, E.Pisano, A.Olianas, M.Pellegrini, S.Nemolato,C.W.Heizmann,G.Faa and I.Messana. Mol. Cell. Proteomics (2011) Jan;10(1):M110.003467.Epub2010 Oct 13 |
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| Keywords / Suchbegriffe | Calcium, EF-hand, S100 proteins, RAGE, Alzheimer's disease, Cancer, Diagnostic | ||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Other links to external web pages | http://www.ulb.ac.be/assoc/ecs/ | ||
| Funding source(s) / Unterstützt durch |
No project-specific funding |
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| Duration of Project / Projektdauer | Jan 2012 to Dec 2014 |