Schäfer
Fakultäten » Medizinische Fakultät » Kinderspital Zürich: Medizinische Klinik » Onkologie, Abteilung » Prof. Dr. Felix Niggli » Schäfer
Completed research project
| Title / Titel | Subclass prediction in paediatric acute lymphoblastic leukaemia using gene expression profiling | ||||
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| Abstract (PDF, 14 KB) | |||||
| Summary / Zusammenfassung | Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy . Treatment stratification is based on various risk factors. Recently it was shown that disappearance of minimal residual disease after the begin of treatment may be one of the strongest predictors for the success of the long term outcome. We therefore would like to combine expertise in detection of minimal residual disease in patients with ALL with recent advances in cDNA-based gene expression profiling. The goal of this project will be to use gene expression profiling at diagnosis to predict subgroups of paediatric ALL patients according to risk categories previously established using PCR-based minimal residual disease detection. | ||||
| Keywords / Suchbegriffe | microarray, gene expression profiling, minimal residual disease, acute lymphoblastic leukaemia | ||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
Foundation Krebsliga Kanton Zürich |
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| Duration of Project / Projektdauer | Nov 2002 to Oct 2004 |