Reichmann
Fakultäten » Medizinische Fakultät » Kinderspital: Chirurgische Klinik » TBRU » PD Dr. Ernst Reichmann » Reichmann
Completed research project
| Title / Titel | Engineering autologous skin composites | ||
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| Abstract (PDF, 14 KB) | |||
| Summary / Zusammenfassung | Despite the continued development of skin-expansion techniques, a suitable skin substitute could not only substantially improve the chances of burn survival but also lead to a better recovery of function and appearance for other surgical procedures. Presently, only autologous full-thickness skin grafts, free flaps or pedicle flaps restore all of the structures and functions of intact skin, but treatment sites and donor sites must be equal in size. In contrast, cultured skin substitutes can provide large quantities of grafts for wound treatment, but restore only a subset of anatomic structures and physiologic functions. Combining the methods of basic cell biology and experimental surgery, we are focussing on the development of a novel autologous dermo-epidermal skin substitute that: a) contains a functional epidermal stem cell compartment b) shows rapid vascularization after transplantation c) develops a robust dermo-epidermal junction Weitere Informationen |
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| Publications / Publikationen | Pontiggia L, Biedermann T, Meuli M, Widmer D, Böttcher-Haberzeth S, Schiestl C, Schneider J, Braziulis E, Montaño I, Meuli-Simmen C, Reichmann E. Markers to evaluate the quality and self-renewing potential of engineered human skin substitutes in vitro and after transplantation. J Invest Dermatol. 2009 Feb;129(2):480-90.Schneider J, Biedermann T, Widmer D, Montano I, Meuli M, Reichmann E, Schiestl C. Matriderm® versus Integra®: a comparative experimental study. Burns. 2009 Feb;35(1):51-7.Montano I, Schiestl C, Schneider J, Pontiggia L, Luginbühl J, Biedermann T, Böttcher-Haberzeth S, Braziulis E, Meuli M, Reichmann E. Formation of human capillaries in vitro: The engineering of pre-vascularized matrices. Tissue Engineering Part A. 2010 Jan; 16 (1): 269-282.Biedermann T, Pontiggia L, Böttcher-Haberzeth S, Tharakan S, Braziulis E, Schiestl C, Meuli M, and Reichmann E. Human eccrine sweat gland cells can reconstitute a stratified epidermis. J Invest Dermatol. 2010 Aug;130(8):1996-2009.Weber AD, Pontiggia L, Biedermann T, Schiestl C, Meuli M, Reichmann E. Determining the origin of cells in tissue engineered skin substitutes: a pilot study employing in situ hybridization. Pediatr Surg Int. 2010 Nov 12. [Epub ahead of print]Tharakan S, Pontiggia L, Biedermann T, Böttcher-Haberzeth S, Schiestl C, Reichmann E, Meuli M. Transglutaminases, involucrin, and loricrin as markers of epidermal differentiation in skin substitutes derived from human sweat gland cells. Pediatr Surg Int. 2010 Jan; 26 (1): 71-77.Böttcher-Haberzeth S, Biedermann T, Reichmann E. Tissue engineering of skin. Burns. 2010 Jun;36(4):450-60. Epub 2009 Dec 22. Review.Böttcher-Haberzeth S, Biedermann T, Reichmann E. Review: Wege zu einer neuen Haut: Von den zellbiologischen Grundlagen über Tissue Engineering zu einem neuen Hautsubstitut. Paediatrica. 2009; 20 (4): 57-61. |
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| Keywords / Suchbegriffe | tissue engineering, dermo-epidermal composite, extracellular matrix, | ||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Other links to external web pages | http://www.skingineering.ch/home.html | ||
| Funding source(s) / Unterstützt durch |
Forschungskredit der Universität Zürich, EU, Other Public Sources (e.g. Federal or Cantonal Agencies), Foundation |
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| Duration of Project / Projektdauer | Dec 2001 to Dec 2011 |