Current Research Project

Title / Titel
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Identifying, isolating and maintaining the epidermal stem cell compartment
Summary / Zusammenfassung
A central issue of our research is the identification, maintenance and/or enrichment of (adult) stem cells in vitro. Recent data suggest that the use of stem cells grown in appropriate stem cell ‘niches’ may solve current problems occurring with in vitro reconstructed tissue equivalents. Our goal is to contribute to a better understanding of stem cell regulation at both the molecular and cellular level.
Publications / Publikationen
Pontiggia L, Biedermann T, Meuli M, Widmer D, Böttcher-Haberzeth S, Schiestl C, Schneider J, Braziulis E, Montaño I, Meuli-Simmen C, Reichmann E. Markers to evaluate the quality and self-renewing potential of engineered human skin substitutes in vitro and after transplantation. J Invest Dermatol. 2009 Feb;129(2):480-90.

Schneider J, Biedermann T, Widmer D, Montano I, Meuli M, Reichmann E, Schiestl C. Matriderm® versus Integra®: a comparative experimental study. Burns. 2009 Feb;35(1):51-7.

Montano I, Schiestl C, Schneider J, Pontiggia L, Luginbühl J, Biedermann T, Böttcher-Haberzeth S, Braziulis E, Meuli M, Reichmann E.
Formation of human capillaries in vitro: The engineering of pre-vascularized matrices.
Tissue Engineering Part A. 2010 Jan; 16 (1): 269-282.

Tharakan S, Pontiggia L, Biedermann T, Böttcher-Haberzeth S, Schiestl C, Reichmann E, Meuli M.
Transglutaminases, involucrin, and loricrin as markers of epidermal differentiation in skin substitutes derived from human sweat gland cells.
Pediatr Surg Int. 2010 Jan; 26 (1): 71-77.

Böttcher-Haberzeth S, Biedermann T, Reichmann E.
Review: Wege zu einer neuen Haut: Von den zellbiologischen Grundlagen über Tissue Engineering zu einem neuen Hautsubstitut.
Paediatrica. 2009; 20 (4): 57-61.

Keywords / Suchbegriffe
melting graft, epidermal stem cell, cell sorting, niche
Project Leadership and Contacts /
Projektleitung und Kontakte
Dr. E. Reichmann (Project Leader)Ernst.Reichmann@kispi.uzh.ch
Other Links to external Webpages
http://www.skingineering.ch/
Funding Source(s) /
Unterstützt durch
Forschungskredit der Universität Zürich, EU, Other Public Sources (e.g. Federal or Cantonal Agencies), Foundation
 
Duration of Project / Projektdauer
Dec 2001 to Dec 2011

© Universität Zürich, 12. Februar 2010, Impressum