Bonanomi Nadal

Fakultäten » Medizinische Fakultät » Kinderspital Zürich: Medizinische Klinik » Infektiologie, Abteilung » Prof. Dr. David Nadal » Bonanomi Nadal

Completed research project

Title / Titel	Screening, identification and characterization of host genes regulating tumor formation associated with Epstein-Barr virus
PDF	Abstract (PDF, 14 KB)
Summary / Zusammenfassung	The proposed project aims to test the hypothesis that Epstein-Barr virus (EBV)-associated tumor formation is driven by an altered regulation of host genes in immune reactive cells. Thus, we will infect tonsil histocultures iatrogenically immunosuppressed or not with EBV replicated in cell cultures, sort T and B lymphocytes and screen the human transcriptome using microchip technology, in an attempt to identify genes differentially regulated during the formation of EBV-associated tumors.
Keywords / Suchbegriffe	Epstein-Barr virus, tumor, cytokines, pathogenesis, microchip, gene expression, tonsil histocultures
Project leadership and contacts / Projektleitung und Kontakte	Dr. A. Bonanomi (Project Leader) athos.bonanomi@bli.uzh.ch PD Dr. med. F. Niggli felix.niggli@kispi.uzh.ch Prof. Dr. med. B. Odermatt Bernhard.Odermatt@pty.usz.ch Prof. Dr. med. D. Nadal (Project Leader) david.nadal@kipsi.uzh.ch
Funding source(s) / Unterstützt durch	Foundation Sassella-Stiftung
Duration of Project / Projektdauer	Jan 2003 to Dec 2004