Reichmann
Fakultäten » Medizinische Fakultät » Kinderspital: Chirurgische Klinik » TBRU » PD Dr. Ernst Reichmann » Reichmann
Completed research project
| Title / Titel | Engineering autologous bioartificial skin substitutes | ||||
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| Abstract (PDF, 14 KB) | |||||
| Summary / Zusammenfassung | Despite the continued development of skin-expansion techniques, a suitable skin substitute could not only substantially improve the chances of burn survival but also lead to a better recovery of function and appearance for other surgical procedures. Presently, only autologous full-thickness skin grafts, free flaps or pedicle flaps restore all of the structures and functions of intact skin, but treatment sites and donor sites must be equal in size. In contrast, cultured skin substitutes can provide large quantities of grafts for wound treatment, but restore only a subset of anatomic structures and physiologic functions. Combining the methods of basic cell biology and experimental surgery, we are focussing on the development of a novel autologous dermo-epidermal skin substitute that: a) contains a functional epidermal stem cell compartment b) shows rapid vascularization after transplantation c) develops a robust dermo-epidermal junction |
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| Publications / Publikationen | Maschler, S., Wirl, G., Spring, H., Defilippi P., Sordat, I., Danielopol A., and Reichmann, E. (2005). The non-polarized expression of wound-specific integrins confers tumor cell invasiveness. Oncogene 24:2032-2041.Reichmann E., Gobet R., Schneider J., (2005). Tissue Engineering: Utopie oder Realität? J Urol Urogynäkol (in press). |
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| Keywords / Suchbegriffe | tissue engineering, dermo-epidermal composite, extracellular matrix, | ||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Other links to external web pages | http://www.skingineering.ch | ||||
| Funding source(s) / Unterstützt durch |
Forschungskredit der Universität Zürich, Other Public Sources (e.g. Federal or Cantonal Agencies), Foundation |
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| Duration of Project / Projektdauer | Dec 2001 to Dec 2005 |