Brunner Seeger

Fakultäten » Medizinische Fakultät » Neuropathologie, Institut für » Prof. Dr. Adriano Aguzzi » Brunner Seeger

Completed research project

Title / Titel	Discovery and quantification of TSE markers using mass spectrometry
PDF	Abstract (PDF, 14 KB)
Summary / Zusammenfassung	The technologies used for the sensitive quantification of PrPSc will be exploited for the identification and detection of surrogate markers specific for transmissible spongiform encephalopathies (TSEs). These marker proteins will allow for ante mortem diagnosis of TSEs. We will focus exclusively on the urinary proteome, which is less complex than that of blood. Candidate surrogate markers in urine be validated to be specific for TSEs and the quantification protocol established for the quantification of PrPSc will be adapted.
Project leadership and contacts / Projektleitung und Kontakte	Erich Brunner (Project Leader) erich.brunner@usz.ch Harald Seeger (Project Leader) harald.seeger@usz.ch Prof. A. Aguzzi adriano@pathol.uzh.ch
Other links to external web pages	http://www.uzh.ch/pathol/neuropathologie/d/index.html
Funding source(s) / Unterstützt durch	Forschungskredit der Universität Zürich, Others Department of Defense, USA
Duration of Project / Projektdauer	May 2003 to Apr 2006