Discovery and quantification of TSE markers using mass spectrometry

Completed Research Project

Title / Titel: Discovery and quantification of TSE markers using mass spectrometry

Summary / Zusammenfassung: The technologies used for the sensitive quantification of PrPSc will be exploited for the identification and detection of surrogate markers specific for transmissible spongiform encephalopathies (TSEs). These marker proteins will allow for ante mortem diagnosis of TSEs. We will focus exclusively on the urinary proteome, which is less complex than that of blood. Candidate surrogate markers in urine be validated to be specific for TSEs and the quantification protocol established for the quantification of PrPSc will be adapted.

Project Leadership and Contacts / Projektleitung und Kontakte

Erich Brunner (Project Leader)	erich.brunner@usz.ch
Harald Seeger (Project Leader)	harald.seeger@usz.ch
Prof. A. Aguzzi	adriano@pathol.uzh.ch

Other Links to external Webpages: http://www.uzh.ch/pathol/neuropathologie/d/index.html

Funding Source(s) / Unterstützt durch: Forschungskredit der Universität Zürich, Others
Department of Defense, USA