Zeller

Fakultäten » Medizinische Fakultät » Neuropathologie, Institut für » Prof. Dr. Adriano Aguzzi » Zeller

Completed research project

Title / Titel	Are Langerhans cells implicated in transport of PrpSC from periphery to lymphoid organs?
PDF	Abstract (PDF, 14 KB)
Summary / Zusammenfassung	Langerhans cells belong to the so called professional antigen presenting cells (APCs) of the immune system. They are phagocytic dendritic cells found in the epidermis of the skin. They can migrate from the epidermis to the regional lymph nodes via the different lymphatics. In the lymph node the differentiate into dendritic cells. There is an open debate, if dendritc cells indeed play a role in the transport and accumulation of PrpSc. To exclusively investigate the role of Langerhans cells in prion pathogenesis we will carry out epidermal and peripheral inoculations using transgenic mice which specifically lack Langerhans cells (Id-2 knockout mice).
Keywords / Suchbegriffe	Langerhans cells, Id-2, PrpSc
Project leadership and contacts / Projektleitung und Kontakte	Nicolas Zeller (Project Leader) nicolas.zeller@usz.ch Mathias Heikenwälder mathias.heikenwaelder@usz.ch Prof. A. Aguzzi ardiano@pathol.uzh.ch
Other links to external web pages	http://www.uzh.ch/pathol/neuropathologie/d/index.html
Funding source(s) / Unterstützt durch	Others
In collaboration with / In Zusammenarbeit mit	Dr. Marco Prinz, Inst. of Neuropathology, University of Göttingen Germany
Duration of Project / Projektdauer	Feb 2002 to Jan 2005