Seeger Maissen

Fakultäten » Medizinische Fakultät » Neuropathologie, Institut für » Prof. Dr. Adriano Aguzzi » Seeger Maissen

Completed research project

Title / Titel	Identification of Interaction Partners of the Prion Protein Homologue Doppel
PDF	Abstract (PDF, 14 KB)
Summary / Zusammenfassung	The function of the cellular prion protein (PrPc) remains poorly understood despite intensive research. PrPc deficient mice do not show obvious abnormalities and thus fail to provide convincing information regarding the natural role of this protein. The recently discovered prion homologue Doppel (Dpl) harbours a structure strikingly similar to neurotoxic amino-truncated PrPc and also induces neurodegeneration in vivo in a PrPc dependent fashion. Dpl is physiologically expressed in the testis and mice deficient for this protein are sterile. However the molecular mechanism for this phenomenon have not been elucidated so far. To identify interaction partners of Dpl we have performed a yeast-two-hybrid screen using a mouse testis library. Currently we are further investigating candidates that we have identified by this screen.
Project leadership and contacts / Projektleitung und Kontakte	Dr. Harald Seeger (Project Leader) harald.seeger@usz.ch Manuela Maissen (Project Leader) manuela.maissen@usz.ch Prof. A. Aguzzi adriano.aguzzi@usz.ch
Other links to external web pages	http://www.neuropathologie.usz.ch/
Funding source(s) / Unterstützt durch	Forschungskredit der Universität Zürich
In collaboration with / In Zusammenarbeit mit	Prof I. Stagljar, Institute of Veterinary Biochemistry, University Zürich Switzerland
Duration of Project / Projektdauer	Apr 2002 to Mar 2005