Schoenle Schoenle
Fakultäten » Medizinische Fakultät » Kinderspital Zürich: Medizinische Klinik » Endokrinologie/Diabetologie, Abteilung » Prof. Dr. Eugen Schönle » Schoenle Schoenle
Current research project
| Title / Titel | The Zurich Longitudinal Study on Cognitive Development in Children with Type 1 Diabetes Mellitus Diagnosed at Young Age | ||||||||
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| Abstract (PDF, 14 KB) | |||||||||
| Summary / Zusammenfassung | Good metabolic control in diabetic children is crucial already during pre-puberty in order to prevent diabetic complications later in life. However, tight metabolic control may increase the risk of severe hypoglycemia, which might be responsible for impaired intellectual perform-ance later on. The purpose of this prospective longitudinal study was to evaluate the signifi-cance of long-term metabolic control and hypoglycemia for intellectual and neuromotor de-velopment of young diabetic children. The study started in 1984 and since then a total of 223 children have been involved representing an actual experience of 1819 patient-years at the end of the year 2011. The tests are performed each year shortly after birthday. The drop-out rate over all the years is 11.2%, primarily because the families left the Zurich area. Up to now, the test series has been completed by 122 children at age 16 years. This allows now to start the longitudinal evaluation in a small sample of children as the patients have to investigated according to sex and age at diagnosis >6 years or between 6 and 10 years. First results could be published recently and led to the following conclusions: Males, but not females, with type 1 diabetes diagnosed at young age show a decline of intellectual performance in comparison with non-diabetic controls. Brain development in diabetic males diagnosed at young age seemed to be less affected by episodes of severe hypoglycemia rather than by the severity of metabolic condition at presentation of the disease and by long-term high average of blood glucose. As the study is ongoing these intriguing results will have to be verified by larger groups. However, this will take time as the most important character is the longitudinal evaluation of the study. | ||||||||
| Publications / Publikationen | Schoenle, E.J., Schoenle, D. Molinari, L., Largo, R.H.: Impaired intellectual development in children with type 1 diabetes mellitus: association with high glycated hemoglobin and gender, but not with severe hypoglycemic episodes: Diabetologia 2002; 45:108-114 | ||||||||
| Keywords / Suchbegriffe | Child, diabetes, longitudinal, intellectual development, cognitive development, gender, hypoglycemia, glycated hemoglobin, ketoacidosis | ||||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
SNF (Personen- und Projektförderung), Private Sector (e.g. Industry) |
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| Duration of Project / Projektdauer | Sep 1984 to Jun 2015 |