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Schmitt

Fakultäten » Medizinische Fakultät » Kinderspital Zürich: Medizinische Klinik » Neuropädiatrie, Abteilung » Prof. Dr. Eugen Boltshauser (emeritiert) » Schmitt

Completed research project

Title / Titel EEG changes in children after cardiac surgery with cardiopulmonary bypass (CPB)
PDF Abstract (PDF, 14 KB)
Summary / Zusammenfassung Cardiac surgery with CPB is associated neurological deficits in 1-20% of the patients. The reasons and pathomechanisms of the neurological deficits are not completely understood. We used continuous intra- and postoperative EEG registration in children with cardiac surgery and CPB and observed a distinct rise of delta-subdelta activity in most children between 10 and 30 hrs after surgery mostly persisting till the end of the 48-72 h recording. We analyse the EEG data and compare the data with clinical and biochemical parameter.
Publications / Publikationen Schmitt, B., Finckh, B., Christen, S., Lykkesfeldt, J., Schmid, E.R., Bauersfeld, U., Critelli, H., Latal, B., Gessler, P., Molinari, L. (2005). Electroencephalographic changes after pediatric cardiac surgery with cardiopulmonary bypass: is slow wave activity unfavourable? Pediatr Res 58. 771-778

Christen, S., Finckh, B., Lykkesfeldt, J., Gessler, P., Frese-Schaper, M., Nielsen, P., Schmid, E.R., Schmitt, B. (2005). Oxidative stress precedes peak systemic inflammatory response in pediatric patients undergoing cardiopulmonary bypass operation. Free Radic Biol Med, 38, 1323-1332.

Schmitt, B., Bauersfeld, U., Fanconi, S., Wohlrab, G., Huisman, T. A., Bandtlow, C., Baumann, P., Superti-Furga, A., Martin, E., Arbenz, U., et al. (1997). The effect of the N-methyl-D-aspartate receptor antagonist dextromethorphan on perioperative brain injury in children undergoing cardiac surgery with cardiopulmonary bypass: results of a pilot study. Neuropediatrics 28, 191-197

Schmitt, B., Bauersfeld, U., Schmid, E. R., Tuchschmid, P., Molinari, L., Fanconi, S., and Bandtlow, C. (1998). Serum and CSF levels of neuron-specific enolase (NSE) in cardiac surgery with cardiopulmonary bypass: a marker of brain injury? Brain Dev 20, 536-539

Schmitt, B., Jenni, O. G., Bauersfeld, U., Schupbach, R., and Schmid, E. R. (2002). Spindle activity in children during cardiac surgery and hypothermic cardiopulmonary bypass. J Clin Neurophysiol 19, 547-552
Project leadership and contacts /
Projektleitung und Kontakte
Prof. Dr. B. Schmitt (Project Leader) bernhard.schmitt@kispi.uzh.ch
Funding source(s) /
Unterstützt durch		 Others
no funding
In collaboration with /
In Zusammenarbeit mit
Dr rer.nat. Barbara Finckh, Free Radical Task Force, Pediatric Department, University of Hamburg Germany

PD Dr. St. Christen, Institute for Infectious Diseases, University of Bern

Switzerland

Prof. Dr. E.R. Schmid, Institute for Anaesthesiology, University of Zurich

Switzerland
Duration of Project / Projektdauer Jan 2002 to Dec 2005
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