Vollenweider Kometer
Fakultäten » Medizinische Fakultät » Psychiatrische Universitätsklinik » Affektive Erkrankungen und Allgemeinpsychiatrie Zürich Ost, Klinik für » Prof. Dr. Daniel Hell (emeritiert) » Vollenweider Kometer
Completed research project
| Title / Titel | A dose-response, placebo-controlled EEG investigation of the brain activity due to psilocybin administration in normals | ||||||
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| Abstract (PDF, 14 KB) | |||||||
| Summary / Zusammenfassung | Psilocybin causes a changed state of consciousness and associated brain activity changes we have previously mapped with PET (Vollenweider et al. 1997). The current project aims to extend these findings by characterizing the specifc localized electrocortical changes seen due to psilocybin administration via high-density EEG recordings. Further, we have found that psilocybin induces a state of consciousness accompanied by phasic periods of altered ego functioning as well as altered processing of visual stimuli such as the perceptually ambiguous binocular rivalry stimulus and visual motion processing. In addition to the dose-response time course analysis of EEG effects due to psilocybin, phasic periods of altered ego functioning/experiences of self and other hallmarks of the altered state elicited by psilocybin will be correlated with their accompanying specific brain activity maps as indexed by spectral power and coherency measures. In addition, gestalt processing will be probed in depth using ERPs (Event-Related Potentials) in response to gestalt vs. non-gestalt visual stimuli (Kanizsa triangles and Mooney faces. Lastly, to more fully characterize the early and late components of general visual processing we use a standard visual-3-stimulus P300 paradigm with standards, targets, and distractors. | ||||||
| Publications / Publikationen | Kometer M., "Elektrophysiologische Korrelate visueller und kognitiver Prozesse und deren Modulation durch Psilocybin." Lizentiatsarbeit der Philosophischen Fakultät der Universität Zürich, Mai 2006Carter OL, Burr DC, Pettigrew JD, Wallis GM, Hasler F, Vollenweider FX. (2005) Using psilocybin to investigate the relationship between attention, working memory, and the serotonin 1A and 2A receptors. Journal of Cognitive Neuroscience 17:10.Cahn R. (2007) Neurophysiolog Correlates to Sensory and Cognitive Processing in Altered States of Consciousness. PhD Thesis, UCSD | ||||||
| Keywords / Suchbegriffe | psilocybin, dose-response, EEG, altered state of consciousness, binocular rivalry, neurophysiology, information processing | ||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
Foundation Heffter Research Institute, USA |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | Jan 2005 to Jun 2008 |