Janett
Fakultäten » Vetsuisse-Fakultät » Nutztiere, Departement für » Fortpflanzungsmedizin, Klinik für » PD Dr. Fredi Janett » Janett
Completed research project
| Title / Titel | Influence of long-term treatment with equine somatotropin (EquiGen®) on gonadal function in stallions with poor semen quality | ||||||||
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| Abstract (PDF, 14 KB) | |||||||||
| Summary / Zusammenfassung | There is good evidence today that growth hormone (GH) and insulin-like growth factor-I (IGF-I) play an important role in reproductive processes of both sexes. The presence of GH receptors has been documented in the ovary as well as in the male reproductive system, including Leydig and Sertoli cells, vas deferens, prostate, ductus epididymis and seminal vesicles. In the stallion, not much is known about the influence of growth hormone in the regulation of reproductive function. The aim of the present study was to investigate the spermatogenic and Leydig cell activity in stallions with impaired semen quality after treatment with equine somatotropin. Experiments were performed using 18 adult clinically healthy stallions with poor semen quality which did not pass breeding soundness evaluation. The animals were randomly divided into a treatment (n=9) and a control (n=9) group. Over a period of 90 days, nine stallions received a daily intramuscular injection of 10 mg recombinant equine somatotropin (EquiGen®, BresaGen Limited, Adelaide, Australia) and 9 control animals were injected with the same amount of physiological saline solution. During and until 2 months after treatment, semen characteristics and daily sperm output as well as plasma testosterone concentrations were determined monthly in all stallions. In addition, testosterone concentration measurement after stimulation with hCG was performed in all animals immediately before and at the end of the treatment period as well as 2 months later. Our results demonstrate that equine somatotropin (EquiGen®) given daily in a dose of 10 mg per animal during 90 days had no significant effect neither on plasma testosterone concentrations and hCG-induced testosterone release nor on semen quality parameters in adult stallions with poor semen characteristics. | ||||||||
| Publications / Publikationen | De Botton D., Janett F., Burger D., Imboden I., Kähn W., Thun R. Influence of long-term treatment with equine somatotropin (EquiGen®) on gonadal function in stallions with poor semen quality. Schweiz. Arch. Tierheilk. 150: 157-165, 2008. De Botton D. Influence of long-term treatment with equine somatotropin (EquiGen®) on gonadal function in stallions with poor semen quality. Dissetation Universität Zürich 2008. |
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| Keywords / Suchbegriffe | Stallion; Semen; Somatotropin; Testosterone | ||||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
Universität Zürich (position pursuing an academic career), Other Public Sources (e.g. Federal or Cantonal Agencies) National Stud Avenches |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | Jul 2005 to Apr 2008 |