Hunt
Fakultäten » Wirtschaftswissenschaftliche Fakultät » Informatik, Institut für » Prof. Dr. Klaus Dittrich (verstorben) » Hunt
Completed research project
| Title / Titel | Data Integration and Visualisation for Functional Genomics | ||||||
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| Abstract (PDF, 14 KB) | |||||||
| Summary / Zusammenfassung | We aim to develop novel database and visualisation technologies which can support interactive search and analysis of very large data sets generated in functional genomics and systems biology research. Suffix sequoia: we are developing new database techniques for exhaustive approximate matching in very large sets of DNA and protein sequences. SyntenyVista: we are extending two viewers, SyntenyVista and DerBrowser, with new visualization techniques for cross-genome sequence and feature comparison, comparison of quantitative trait loci (QTLs) and micro array results across species, and comparison of polymorphisms and existing database annotations. This work involves the design, implementation and testing of new algorithms, and evaluation of these techniques with large data sets and with users, in the context of cardiovascular disease. Example applications include: rat micro array probe mapping, phage display data analysis, visualization of micro array results and QTLs. |
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| Publications / Publikationen | Vascular bed-targeted in vivo gene delivery using tropism-modified adeno-associated viruses, Lorraine M. Work, Hildegard Büning, Ela Hunt, Stuart A. Nicklin, Laura Denby, Nicola Britton, Kristen Leike, Margarete Odenthal, Uta Drebber, Michael Hallek and Andrew H. Baker Molecular Therapy, In Press, Available online 4 January 2006 |
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| Keywords / Suchbegriffe | bioinformatics, suffix tree, database technology, approximate matching, visualisation, functional genomics, synteny | ||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Other links to external web pages | http://www.dcs.gla.ac.uk/~asia | ||||||
| Funding source(s) / Unterstützt durch |
Universität Zürich (position pursuing an academic career), Other Public Sources (e.g. Federal or Cantonal Agencies) Medical Research Council, UKWellcome Trust, UK |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | Oct 2005 to Dec 2006 |