Hofmann-Lehmann
Fakultäten » Vetsuisse-Fakultät » Nutztiere, Departement für » Veterinärmedizinisches Labor » Prof. Dr. Regina Hofmann-Lehmann » Hofmann-Lehmann
Completed research project
| Title / Titel | Low-cost microtest for rapid Helicobacter pylori cultivation and antibiotic susceptibility testing | ||||||
|---|---|---|---|---|---|---|---|
| Abstract (PDF, 14 KB) | |||||||
| Summary / Zusammenfassung | Helicobacter pylori (H. pylori) is a causative agent of gastro-duodenal ulcer disease and an established carcinogen for gastric adenocarcinoma. Diagnostic and treatment of H. pylori infection is an important direction of public health related with large outlay. H. pylori is a fastidious microorganism and its cultivation is technically complicated. For clinical practice, rapid tests such as the non-invasive urease-test or polymerase chain reaction (PCR) specific for Helicobacter were elaborated. At present, physicians usually use empirical treatment schemes in treatment of patients with diagnosed H. pylori infection. Growing resistance of this germ to accepted antibiotics and lack of convenient and rapid antibiotic susceptibility tests result in inefficient therapy and inadequate antibiotic-resistance surveillance. In this connection, return to culture methods seems necessary. The goal of the present study is to design and realize a three-in-one H. pylori combination test in a single microtest comprising an indicator test, a selective medium for rapid cultivation of H. pylori, and an orientational antibiotic susceptibility tests for H. pylori. The intended three-in-one microtest will represent a new low-cost clinical solution, which will be valuable for the healthcare sector in both developed and low-income countries. | ||||||
| Publications / Publikationen | Sainsus, N., V. Cattori, C. Lepadatu, and R. Hofmann-Lehmann. 2008. Liquid culture medium for rapid cultivation of Helicobacter pylori from biopsy specimens. Eur J Clin Microbiol Infect Dis 27:1209-17.N. Sainsus, R. Hofmann-Lehmann, V. Cattori, C. Lepadatu, I.Cararus. Antibioticoterapia raţională în infecţie cu Helicobacter pylori. Accepted for publication – Arta Medica, Moldova, 2008. | ||||||
| Keywords / Suchbegriffe | Helicobacter pylori, culture medium, urease, rapid microtest, antibiotic sensitivity testing | ||||||
| Project leadership and contacts / Projektleitung und Kontakte |
|
||||||
| Funding source(s) / Unterstützt durch |
SNF (Personen- und Projektförderung) SCOPES 2005-2008 |
||||||
| In collaboration with / In Zusammenarbeit mit |
|
||||||
| Duration of Project / Projektdauer | Oct 2005 to Oct 2007 |