Böni Schüpbach
Fakultäten » Medizinische Fakultät » Medizinische Virologie, Institut für » PD Dr. Jürg Böni » Böni Schüpbach
Completed research project
| Title / Titel | Phylogenetic analysis and molecular epidemiology of caprine and ovine lentiviruses circulating in Switzerland based on long sequences in gag and pol and implications for virus eradication programs | ||||||
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| Abstract (PDF, 14 KB) | |||||||
| Summary / Zusammenfassung | We performed a phylogenetic analysis of caprine and ovine lentiviruses using long sequences in gag and pol of 104 new Swiss isolates and six available corresponding database sequences. Forty-five isolates, forming five sequence clusters, were unclassifiable by the present classification. Pairwise DNA distance analysis indicated different categories of relatedness, requiring a new classification system. We propose four principal sequence groups, A-D, which differ by 25-37%. Groups A and B are further divided into subtypes which differ by 15-27%. Group D and four of the seven group A subtypes, A3, A4, A5 and A7, are formed by new Swiss isolates. Molecular epidemiology revealed that Swiss B1 strains differed no more from French, Brazilian or US strains than from each other, suggesting virus propagation through international livestock trade. Furthermore, infection of goats by subtypes A3 or A4 was significantly associated with documented contact with sheep, which also harbor these subtypes, thus indicating regularly occurring sheep-to-goat transmission. Weitere Informationen |
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| Publications / Publikationen | Weitere Informationen | ||||||
| Keywords / Suchbegriffe | caprine arthritis encephalitis, CAEV, visna-maedi virus, MVV, small ruminant lentivirus, SRLV, goat, sheep, PCR, molecular epidemiology, phylogenetic analysis, virus eradication | ||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Other links to external web pages | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15220425&query_hl=5&itool=pubmed_docsum | ||||||
| Funding source(s) / Unterstützt durch |
Other Public Sources (e.g. Federal or Cantonal Agencies), Others |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | Sep 1998 to Dec 2002 |