Jiricny
Fakultäten » Medizinische Fakultät » Molekulare Krebsforschung, Institut für » Prof. Dr. Josef Jiricny » Jiricny
Completed research project
| Title / Titel | DNA damage response and repair mechanisms. | ||
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| Abstract (PDF, 14 KB) | |||
| Summary / Zusammenfassung | The main objective is to obtain an integrated perception of the individual mechanisms of DNA repair, their complex interplay and biological impact, using approaches ranging from structural biology to systems biology. Translation of the results that we obtain is expected to contribute to an improved quality of life through possible identification of genetic markers for assessment of susceptibility to occupational hazards and disease, discovery of promising targets for therapy, improved diagnostic and prognostic procedures for genetic disorders, and early diagnosis and prevention of cancer and other ageing-related diseases. We have also included a strong training component in the project to invest in young talented students, who may become the leaders of tomorrow. | ||
| Publications / Publikationen | Mismatch repair-dependent processing of methylation damage gives rise to persistent single-stranded gaps in newly-replicated DNA. Mojas, N., Lopes, M. and Jiricny, J. (2007) Genes & Development, in press |
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| Keywords / Suchbegriffe | DNA metabolism, DNA repair, DNA damage signalling | ||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Other links to external web pages | http://www.dna-repair.nl/kick_off/intro.swf | ||
| Funding source(s) / Unterstützt durch |
EU |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | May 2005 to Apr 2009 |