Aguzzi
Fakultäten » Medizinische Fakultät » Neuropathologie, Institut für » Prof. Dr. Adriano Aguzzi » Aguzzi
Completed research project
| Title / Titel | Germinal center B cells are dispensable in prion transport and neuroinvasion | ||||
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| Abstract (PDF, 14 KB) | |||||
| Summary / Zusammenfassung | Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative diseases of animals and humans. Many TSEs are initiated by prion replication in the lymphoreticular system (LRS). The cellular and molecular prerequisites for prion trafficking within the LRS are not fully understood. Here we have manipulated CD40 and its ligand to investigate whether genetic or pharmacological ablation of germinal center B cells (GCBs), which migrate into and out of germinal centers, influences prion pathogenesis. In contrast to previous reports, no alteration of prion pathogenesis was detected in mice lacking CD40L and in mice treated with anti-CD40L antibodies. These results suggest that GCBs alone do not impact peripheral splenic prion transport, replication efficiency, or neuroinvasion, and point to other mechanisms effecting prion transport from lymphoreticular sites of replication to the nervous system. | ||||
| Keywords / Suchbegriffe | Prion disease, intraperitoneal prion transport | ||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
Nachwuchsförderungskredit der Universität Zürich, Other Public Sources (e.g. Federal or Cantonal Agencies), Foundation |
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| Duration of Project / Projektdauer | Jan 2007 to Dec 2008 |