ten Cate Saurenmann
Fakultäten » Medizinische Fakultät » Kinderspital Zürich: Medizinische Klinik » Rheumatologie, Abteilung » Dr. Rotraud Katharina (Traudel) Saurenmann » ten Cate Saurenmann
Completed research project
| Title / Titel | Genetic prognostic factors in Juvenile Idiopathic Arthritis - the PROFA-study | ||||||
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| Abstract (PDF, 14 KB) | |||||||
| Summary / Zusammenfassung | The aim of the PROFA-study is to determine genetic factors that are associated with the susceptibility to JIA and prognostic factors for the severity of the course of JIA. Polymorphisms in different genes that code for proteins that are involved in the immune response, will be studied. Not only single nucleotide polymorphisms (SNP's) will be studied, but also the combination of different mutations (haplotypes). The reconstruction of a haplotype requires the known genotypes of both parents (first degree family members). We hope to find an association between different polymorphisms or haplotypes and the susceptibility and/ or severity of JIA. The next step will be to study the functionality of the polymorphism or haplotype that is found. When an association with a functional polymorphism or haplotype is found, than this can reveal part of the pathogenesis of Juvenile Idiopathic Arthritis. |
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| Publications / Publikationen | Association of the autoimmunity locus 4q27 with juvenile idiopathic arthritis. Albers HM, Kurreeman FA, Stoeken-Rijsbergen G, Brinkman DM, Kamphuis SS, van Rossum MA, Girschick HJ, Wouters C, Saurenmann RK, Hoppenreijs E, Slagboom P, Houwing-Duistermaat JJ, Verduijn W, Huizinga TW, Ten Cate R, Toes RE, Schilham MW Arthritis Rheum. 2009 Mar;60(3):901-4The clinical course and prognostic value of disease activity in the first two years in different subtypes of juvenile idiopathic arthritis. Albers HM, Brinkman DMC, Kamphuis SSM, Suijlekom-Smit LWA, Van Rossum MAJ, Hoppenreijs E, Girschick HJ, Wouters C, Saurenmann RK, Houwing-Duistermaat JJ, Huizinga TWJ, Schilham MW, Ten Cate R. Arthritis Care & Research 2010;62 (2);Feb 2010;204-212 |
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| Keywords / Suchbegriffe | juvenile idiopathic arthritis, prognosis, single nucleotid polymorphism, genetic susceptibility, | ||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
Other Public Sources (e.g. Federal or Cantonal Agencies) |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | Oct 2007 to Dec 2010 |