Moeller
Fakultäten » Medizinische Fakultät » Kinderspital Zürich: Medizinische Klinik » Pneumologie » PD Dr. Alexander Möller » Moeller
Completed research project
| Title / Titel | Exhaled Nitric oxide is elevated in young preschool children with persistent asthma at school age | ||||||||
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| Abstract (PDF, 14 KB) | |||||||||
| Summary / Zusammenfassung | Background: Respiratory symptoms are common in early childhood. The clinical characterization of disease presentation and hence, its likely disease progression has so far been proven difficult. We have recently shown that wheezy young children less than 4 years of age with a stringent index for the prediction of asthma at school age have elevated levels of FeNO compared to children with recurrent wheeze and a loose index for the prediction of asthma at school age or children with recurrent cough. Objective: To follow up children from the previous study in order to assess persistent asthma at school-age and to evaluate the predictive value of FeNO measured in early preschool-age for the persistence of asthma at school age. Methods: All children from the original study now being at the age of 6-10 years were followed up by a phone call and interviewed using a modified ISAAC questionnaire. They were asked to take part in an additional visit in order to perform skin prick testing (SPT), lung function and FeNO measurements. FeNO was assessed by a single breath on-line method according to ATS/ERS recommendations. SPT was performed for five common allergens including birch and hazel, 6-grass mix, animal dander of cat and dog, and dust mite. Spirometry was measured according to current recommendations (Masterlab (Jaeger, Wuerzburg, Germany). |
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| Publications / Publikationen | Exhaled nitric oxide distinguishes between subgroups of preschool children with respiratory symptomsWeitere Informationen | ||||||||
| Keywords / Suchbegriffe | Exhaled nitric oxide, preschool children, infants, asthma, development | ||||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
No project-specific funding |
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| Duration of Project / Projektdauer | Aug 2007 to Feb 2009 |